I fired up Local by Flywheel again recently to test some changes to a plugin; as it started I received a series of errors:

Error
Uh-oh! We ran into a hiccup when trying to start the Local Machine.
Unable to start the VM: C:Program FilesOracleVirtualBoxVBoxManage.exe startvm local-by-flywheel --type headless failed:

Error
Uh-oh! We ran into a hiccup when trying to start the Local Machine.
VBoxManage.exe: error: Raw-mode is unavailable courtesy of Hyper-V.
(VERR_SUPDRV_NO_RAW_MODE_HYPER_V_ROOT)

Error
Uh-oh! We ran into a hiccup when trying to start the Local Machine.
VBoxManage.exe: error: Details: code E_FAIL (0x80004005), component ConsoleWrap,
interface IConsole

Error
Uh-oh! We ran into a hiccup when trying to start the Local Machine.
Details: 00:00:01.332083 Power up failed (vrc=VERR_SUPDRV_NO_RAW_MODE_HYPER_V_ROOT, rc=E_FAIL (0X80004005))
Seeing the references to Hyper-V in the second and fourth error messages reminded me that I’d needed to stop Hyper-V before installing Local by Flywheel.
I stopped it running, rebooted the PC and was able to start Local by Flywheel without further issue.