The version of Node Builder available to download, is Node Builder 2011. Neither the online nor downloadable manual specify any system requirements other than Microsoft Dynamics GP.
It’s important to note that Node Builder 2011 is not compatible with a named system database as it precedes this functionality.
A 2015 version of Node Builder is semi-available if required; I found this out by speaking to eOne’s support team. If you need to develop custom nodes against a named system database, you will need to contact eOne support to get a copy of Node Builder 2015.